The Effect of Hyperthyroidism on Bone Mineral Density in Premenopausal Women

Adequate concentrations of thyroid hormones are necessary for bone development and maturation whereas excess concentrations enhance bone turnover and cause osteoporosis [1]. Although this phenomenon is most obvious in patients with overt hyperthyroidism (H) some studies suggest that even mild subclinical hyperthyroidism (SH) is associated with increased bone resorption [2] and accelerated bone loss [3,4]. Although the loss of bone mineral density in postmenopausal women with hyperthyroidism is well defined [5], the reports on the results of SH in premenopausal women are contradictory. In suggestion to the actions of thyroid hormones, subclinical hyperthyroidism has to have similar osteoporotic effects in premenopausal period.